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Updated: Feb 20, 2026

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
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瑞克是一种GPNMB受体,驱动MASH

Yue Xi1,2, Waner Zeng1,2, Jie Luo1,2

  • 1State Key Laboratory of Metabolism and Regulation in Complex Organisms, College of Life Sciences, Wuhan University, Wuhan, China.

Nature
|February 18, 2026
PubMed
概括

代谢功能障碍相关的胆固醇肝炎 (MASH) 的进展是由糖蛋白非转移性黑色素瘤蛋白B (GPNMB) ectodomain (G-ECD) 结合受体氨酸激酶 (RYK) 驱动的. 针对这个GPNMB-RYK轴为MASH提供了一个有前途的治疗策略.

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