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综合应激反应通过利波卡林2促进免疫逃避

Jozef P Bossowski1, Ray Pillai1,2,3, John Kilian4,5

  • 1Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.

Nature
|February 18, 2026
PubMed
概括

癌细胞使用综合应激反应 (ISR) 和激活转录因子4 (ATF4) 来抵抗治疗. 向ATF4-利波卡林2 (LCN2) 轴可以增强T细胞对瘤的免疫力.

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