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相关概念视频

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Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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相关实验视频

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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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第二次ipsilateral乳腺癌事件:真正的复发,新的初级,或真正的复发? : 乳腺癌局部复发 乳腺癌局部复发

Nina Pujol1, Jocelyn Gal2, Mathieu Gautier1

  • 1Department of Radiation Oncology, Antoine Lacassagne Cancer Centre, University Cote d'Azur, Nice, Cedex, France.

Annals of surgical oncology
|February 18, 2026
PubMed
概括

在初始治疗后,区分真正的复发与新的原发性乳腺癌至关重要. 这项研究发现,真正的复发和新的原发性事件之间没有显著的瘤结果差异,这表明第二种乳腺保护治疗可能是一个选择.

关键词:
双侧乳腺癌复发的情况进行乳腺切除术.新的一级初级.第二种乳腺保护疗法系统性疗法是一种全身疗法.真正的复发是真实的.

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科学领域:

  • 在瘤学瘤学.
  • 乳腺癌研究研究 乳腺癌研究
  • 手术瘤学手术瘤学

背景情况:

  • 在初始乳腺保护治疗 (BCT) 后,准确区分真实复发 (TR) 和新发原发性 (NP) 乳腺癌至关重要.
  • 在第二次ipsilateral乳腺癌事件 (2nd iBCE) 的情况下,存在有限的数据来精确定义TR和NP.

研究的目的:

  • 在患有第二次ipsilateral乳腺癌事件 (2nd iBCE) 的患者中分析瘤组织学和拓学.
  • 为了比较真实复发 (TR) 和新的原发性 (NP) 乳腺癌事件之间的瘤结果.
  • 在晚期真正复发的情况下,评估第二次乳房保护治疗 (BCT) 的可能性.

主要方法:

  • 对接受第二次BCT进行第二次iBCE的患者的回顾性分析.
  • 组织学评估 (类型,等级,激素受体,HER2状态) 和第二次iBCE的地形分析.
  • 瘤结局的比较,包括第二次局部复发 (CI-2nd LR),远程转移性疾病 (CI-DMD),无疾病生存率 (DFS) 和整体生存率 (OS).
  • 系统的文献审查.

主要成果:

  • 在2000年9月至2024年1月期间,分析了113名患者 (76名TR,37名NP).
  • 手术间隔的中位数为149.3个月; 82.3%的第二次iBCE发生在与第一个相距较远的地方.
  • 在TR和NP组之间没有观察到瘤结果 (CI-2nd LR,CI-DMD,DFS,OS) 的显著差异.

结论:

  • 基于组织学和地形学的真实复发 (TR) 和新初级 (NP) 之间的区别可能不会决定不同的治疗方法.
  • 对于那些希望保持乳房的晚期真实复发患者,可以考虑第二次乳房保护治疗 (BCT).