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Updated: Feb 20, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
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综合性多组学定义了黑色素瘤药物反应网络和ARID1A依赖的耐药机制

Charlie George Barker1,2, Sumana Sharma1,3, Ana Mafalda Santos3

  • 1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.

Molecular systems biology
|February 18, 2026
PubMed
概括

黑色素瘤中的ARID1A损失通过改变细胞信号和免疫逃避途径,促进对BRAF/MAPK抑制剂的耐药性. 准PRKD1,JUN和NCK1可以克服这种阻力.

关键词:
在 ARID1A 中.数据整合数据集成药物耐药性 药物耐药性 药物耐药性黑色素瘤是一种黑色素瘤.网络分析 网络分析

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