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基线时的体力活动和前列腺癌在主动监测中的再分类等级风险:来自前性队列研究的结果
Michelle I Higgins1, Zhuo Tony Su2, Mufaddal Mamawala2
1The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. mhiggi26@jhu.edu.
Prostate cancer and prostatic diseases
|February 18, 2026
概括
定期体育活动可能会降低在积极监测 (AS) 的男性前列腺癌 (PCa) 进展的风险. 更高的活动水平独立地降低了进入3级组 (GG3) 疾病的风险.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生活方式 医学 医疗
背景情况:
- 关于身体活动对低风险前列腺癌 (PCa) 在主动监测 (AS) 期间进展的影响的数据有限.
- 目前尚不清楚身体活动是否会影响疾病的进展,而不是饮食和吸烟.
研究的目的:
- 为了研究基线体力活动水平和等级重新分类 (GR) 之间的关联,在AS的1级组 (GG1) PCa的男性中.
- 为了确定体力活动是否会影响PCa的进展,独立于饮食和吸烟状态.
主要方法:
- 对828名男性进行的前性队列研究,其中828名男性患有AS的GG1PCa.
- 使用每周代谢相当的任务小时 (MET-h/wk) 评估体力活动;使用健康饮食指数 (E-HEI) 评估饮食质量.
- 多变量竞争性风险回归分析了体育活动和GR之间的关联,以≥GG2和≥GG3.
主要成果:
- 增加的体力活动 (≥3MET-h/week) 独立地与显著降低的GR风险 ≥GG3.3相关.
- 较高的体力活动显示GR的非显著下降到≥GG2.
- 改善饮食质量 (E-HEI) 也与GR降低至≥GG3有关;吸烟与GR结果无关.
结论:
- 基线增加的体力活动独立地与AS的GG1PCa男性的≥GG3疾病进展的风险较低有关.
- 身体活动等生活方式因素可能在积极监测期间在控制PCa进展方面发挥作用.
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