在冠状动脉疾病中L-carnitine的治疗潜力:系统性审查
Rehab H Werida1,2, Sherouk M Okda3
1Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Damanhour University, Damanhour, 22514, Al Bahaira, Egypt. rehabwrieda@pharm.dmu.edu.eg.
Inflammopharmacology
|February 18, 2026
概括
补充L-carnitine对冠状动脉疾病 (CAD) 患者有潜在的益处,减少死亡率和心律失常. 然而,由于对心力衰竭和心脏复发的结果不一致,需要进一步的研究.
科学领域:
- 心脏病学 心脏病学
- 营养科学 营养科学
- 生物化学 生物化学
背景情况:
- 冠状动脉疾病 (CAD) 是全球死亡的主要原因,由动脉样硬化和氧化应激驱动.
- 氨基酸衍生物L-carnitine (LC) 对于线粒体脂肪酸运输至关重要,并表现出抗氧化和抗炎性质.
研究的目的:
- 在CAD中合成L-卡尼丁补充的机械证据 (抗炎,抗氧化剂) 和临床结果 (死亡率,心律失常).
- 批判性地评估文献中关于L-卡尼对CAD患者心力衰竭和再发作的影响的不一致性.
主要方法:
- 在PubMed和谷歌学者数据库中进行系统的文献搜索,直到2025年7月.
- 包括多种类型的研究 (RCT,元分析,观察性研究) 调查L-卡尼丁对心脏功能,氧化应激,炎症和CAD死亡率的影响.
- 排除非英语论文和研究范围之外的研究,导致分析了21项研究.
主要成果:
- 补充L-卡尼丁与减少炎症标志物,氧化应激和心脏损伤生物标志物有关.
- 在左心室功能和脂质配置文件中注意到了改善.
- 分析表明,全因死亡率,心室节律失常和心痛发作减少,但对心力衰竭和心脏复发的发现不一致.
结论:
- 补充L-卡尼丁可以为患有冠状动脉疾病的患者提供心脏保护作用.
- 进一步的大规模,长期随机试验是必要的,以澄清不一致的临床结果,特别是关于心力衰竭和心肌复发.
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