高清tDCS调节前额前-边缘-状连接,并减少年轻人患有第一发抑郁症的抑郁症
Xianliang Chen1, Huajia Tang1, Jiali Liu2
1Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, National Technology Institute on Mental Disorders, Changsha, Hunan, China.
BMC psychiatry
|February 19, 2026
概括
高清度跨直流刺激 (HD-tDCS) 在年轻成年人中改善了抑郁和焦虑. 这种疗法调节了前额外边缘状状系统内的大脑连接,为其有效性提供了神经生物学证据.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 跨直流刺激 (tDCS) 显示出缓解抑郁症状的希望.
- 在抑郁症中tDCS的精确治疗机制尚未完全理解.
- 调查症状改善和大脑活动变化在第一次情节抑郁症 (FED) 中至关重要.
研究的目的:
- 在高清tDCS (HD-tDCS) 后,研究FED后青少年的症状改善.
- 在FED中检查HD-tDCS后休息状态大脑活动的变化.
- 探索患有抑郁症的年轻成年人的HD-tDCS治疗的神经生物学基础.
主要方法:
- 18名患有FED的年轻人和14名健康对照参与了这项研究.
- 参与者在两周内每天接受10次HD-tDCS治疗.
- 用临床评估和静止状态fMRI来分析功能连接 (FC) 变化.
主要成果:
- 在治疗后观察到抑郁和焦虑得分的显著改善.
- HD-tDCS导致前额外边缘状状系统的功能连接 (FC) 降低.
- 状回形 (FG) 和中前额回形之间减少的FC与症状改善相关.
结论:
- HD-tDCS似乎有效治疗患有第一次抑郁症的年轻人.
- 治疗诱导的症状改善与调节的大脑连接性有关.
- 这项研究提供了神经生物学证据,支持tDCS用于抑郁症治疗.
相关概念视频
Long-term Depression
33.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.4K
Long-term Depression
3.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
3.4K
Attention-Deficit/Hyperactivity Disorder
1.1K
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
1.1K
Depression: Overview
973
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
973
Brain Imaging
775
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
775
Depressive Disorders: MDD and Dysthymia
858
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
858


