怀孕和早产期间的母体氨基酸代谢物:来自两个前性队列研究的结果
Jingnan Chen1,2, Yidan Dong3, Jiajun Zhao1,2
1Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, Zhejiang, China.
BMC medicine
|February 19, 2026
概括
母亲的氨基酸代谢物,特别是较低的Ile-Val和较高的Val-Gly,与早产风险有关. 这些生物标志物显示出改善产前风险评估和预测妊娠持续时间的潜力.
科学领域:
- 生物化学 生物化学
- 生殖医学 生殖医学
- 围产期流行病学 围产期流行病学
背景情况:
- 精确调节母胎氨基酸水平对于胎儿发育至关重要.
- 母亲氨基酸代谢物与妊娠时间/早产风险之间的联系尚不清楚.
研究的目的:
- 为了确定与妊娠时间相关的母体氨基酸代谢物.
- 发现生物标志物来预测跨不同队伍的早产风险.
主要方法:
- 嵌套病例对照研究使用了通吉-华西-舒安出生队列 (THSBC) 和韦斯特莱克精密出生队列 (WeBirth).
- 氨基酸代谢相关代谢物的轨迹分析和回归建模,以评估与妊娠时间和早产的关联.
- 开发和验证一个氨基酸早产预测评分 (APPS).
主要成果:
- 在THSBC中,怀孕中期增加的Ile-Val与更长的妊娠期相关 (0.19周/SD增加),而Val-Gly显示出反向关联 (-0.20周/SD增加).
- 较低的Ile-Val和较高的Val-Gly与早产风险增加显著相关 (OR分别为0.72和1.25).
- 这些发现在WeBirth队列中是一致的,APPS与临床模型相比,显示出更好的早产预测.
结论:
- 循环的母体氨基酸代谢物,包括Ile-Val和Val-Gly,可以作为早产预测生物标志物.
- 这些代谢物对提高产前风险评估和管理具有潜在的临床实用性.
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