营养补充剂对出生时体重非常低的婴儿体内生长的影响:系统审查和网络元分析的协议
Muneerah Satardien1, Michael Mccaul2, Evette Van Niekerk3
1Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Systematic reviews
|February 19, 2026
概括
这次系统审查和网络元分析将比较早产婴儿的营养补充剂,以改善生长. 它旨在提供基于证据的指导,为出生时体重非常低的婴儿提供最佳营养.
科学领域:
- 新生儿营养新生儿营养
- 儿科胃肠病学 儿科胃肠病学
- 基于证据的医学基于证据的医学.
背景情况:
- 对于早产婴儿的最佳营养缺乏共识,导致不同的临床实践.
- 口服宏观和微量营养素补充剂是促进早产婴儿生长的常见干预措施.
- 实践中的重大变化需要对当前的营养补充策略进行审查.
研究的目的:
- 系统地审查和比较口服宏观和微量营养素补充剂在促进早产婴儿产后生长方面的有效性.
- 确定当前对早产婴儿的营养补充建议中的关键知识缺口.
- 为非常低出生体重婴儿 (VLBWI) 提供最佳营养补充策略的基于证据的指导.
主要方法:
- 随机对照试验和前性观察研究的系统审查和网络元分析 (NMA).
- 在数据库和网站搜索2010-2024年间发表的关于VLBWIs (<1500g) 中营养补充的研究.
- 使用随机效应模型的频率主义方法进行网络元分析;用于证据确定性评估的GRADE方法.
主要成果:
- 国家营养管理局将生成营养补充干预措施的比较排名.
- 将评估各种补充剂在改善医院生长中的有效性.
- 结果将以汇总表和Sucra排名的方式呈现.
结论:
- 该NMA将提供基于证据的指导,提供VLBWIs的最佳营养补充.
- 它解决了新生儿营养实践中的关键知识差距.
- 这些发现将有助于标准化和改善早产婴儿的营养支持.
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