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基于生理学的药理动力学虚拟双胞胎方法用于儿科血造干细胞移植中的弗卢达拉宾剂量

Mourad Mseddi1, Christa Nath2,3,4, Khalil Ben Hassine1,5

  • 1CANSEARCH Research Platform for Pediatric Oncology and Hematology, Department of Pediatrics, Gynecology, and Obstetrics, University of Geneva, Geneva, Switzerland.

CPT: pharmacometrics & systems pharmacology
|February 19, 2026
PubMed
概括

这项研究开发了一种基于生理学的药理动力学 (PBPK) 模型,以准确预测在接受血造干细胞移植 (HSCT) 的儿科患者中Fludarabine (流感) 药物暴露的情况. 该模型允许个性化剂量,以改善治疗结果.

关键词:
化学疗法 化疗 化疗弗鲁达拉宾 (Fludarabine) 是一种药物.造血干细胞移植 造血干细胞移植儿科 儿科 儿科基于生理学的药理动力学.虚拟双胞胎是一个虚拟的双胞胎.

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