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Updated: Feb 20, 2026

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
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Published on: February 8, 2018

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对客观反应率和生存终点的基于模型的元分析,以比较非小细胞肺癌中PD-1和PD-L1治疗结果

Richard C Franzese1, Li Qin2, Shuai Fu2

  • 1Clinical Pharmacology Modeling and Simulation, GSK, Upper Providence, Pennsylvania, USA.

CPT: pharmacometrics & systems pharmacology
|February 19, 2026
PubMed
概括

客观反应率 (ORR) 显著预测了转移性非小细胞肺癌 (mNSCLC) 治疗PD-L) 1抑制剂的生存结果. 虽然PD-1抑制剂比PD-L1抑制剂具有数值优势,但差异在统计学上并不显著.

关键词:
比较的有效性比较的有效性.混合效应模型的混合效应模型.基于模型的元分析.瘤学 在瘤学方面.替代终点 替代终点生存分析,生存分析.试验模拟试验的模拟

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