血清前列腺素对认知功能,大脑结构和功能在2型糖尿病中的影响
Xiang Xu1,2, Huijie Yang1,2, Congcong Yu2,3
1Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
The Journal of clinical endocrinology and metabolism
|February 19, 2026
概括
在2型糖尿病患者中,较低的益生菌素 (PRL) 水平与认知能力下降和大脑变化有关. 这表明PRL可能在糖尿病相关的认知功能障碍中发挥作用.
科学领域:
- 神经内分泌学神经内分泌学
- 代谢障碍 代谢障碍 代谢障碍
- 认知神经科学是一种认知神经科学.
背景情况:
- 糖尿病相关认知功能障碍 (DACD) 涉及代谢和神经功能障碍.
- 甲状腺激素 (PRL) 影响葡萄糖调节和神经炎症,可能有助于DACD.
研究的目的:
- 调查血清益乳素 (PRL) 与2型糖尿病 (T2DM) 的认知功能之间的关系.
- 探索潜在的神经成像机制,将PRL与T2DM患者的认知障碍联系起来.
主要方法:
- 分析了1167名T2DM患者 (522人认知正常,418人轻度认知障碍 [MCI]).
- 功能磁共振成像 (fMRI) 评估了247名参与者的大脑结构和功能.
- 结构方程建模 (SEM) 探索了将血清PRL与认知联系起来的机制.
主要成果:
- 血清PRL是T2DM中MCI的独立风险因素.
- 较低的PRL水平与海马和杏仁体体积的减少相关.
- 在最低的PRL组中观察到杏仁体和额叶之间的功能连接性下降.
结论:
- 血清PRL降低与T2DM的认知表现下降有关.
- 较低的PRL水平与大脑结构和功能变化相关,包括海马-杏仁体体积减少和杏仁体连接性受损.
- 在T2DM患者中,PRL通过边缘结构间接影响认知.
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