[童年和青春期的逆境:从有毒压力到临床实践]
Caroline Heiniger1, Charlotte Reith2, Clothilde Hamion3
1Service de pédiatrie générale, Département femme-mère-enfant, Centre hospitalier universitaire vaudois, 1011 Lausanne.
Revue medicale suisse
|February 19, 2026
概括
童年不良经历 (ACE) 可以对长期的健康和行为产生负面影响. 然而,保护因素和支持系统,包括医疗干预措施,可以显著减轻这些有害影响.
科学领域:
- 童年发展儿童的发展.
- 公共卫生 公共卫生
- 神经科学是一个神经科学.
背景情况:
- 童年不良经历 (ACE) 是普遍存在的,并与持久的身体和心理健康问题有关.
- 通过诸如慢性压力反应激活等机制,ACEs有助于风险行为.
- 在ACE之后的大脑,免疫和表观遗传的改变增加了长期的健康脆弱性.
研究的目的:
- 总结童年不良经历对健康和行为的影响.
- 探索潜在的生物和表观遗传机制.
- 突出保护因素和干预措施在减轻ACEs影响中的作用.
主要方法:
- 关于不良童年经历的文献综述.
- 分析包括应激反应,神经生物学,免疫学和表观遗传变化的机制.
- 检查保护因素及其对健康结果的影响.
主要成果:
- ACE与显著的长期身体和心理健康缺陷有关.
- 慢性压力,大脑功能的改变,免疫失调和表观遗传修饰均介于ACE的影响.
- 保护因素,如强大的社会支持和积极的经验,可以缓冲负面结果.
结论:
- ACEs的负面后果并不是不可改变的.
- 医疗保健专业人员对于培养父母和社会支持等保护因素至关重要.
- 促进儿童积极体验对于长期健康和发展至关重要.
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