甲状腺功能与认知障碍患者的认知和神经精神症状的关联
Yu-Ru Lin1, Ming-Che Chang2, Wen-Fu Wang3
1Department of Medical Education, Changhua Christian Hospital, Changhua, Taiwan.
Neuropsychiatric disease and treatment
|February 19, 2026
概括
甲状腺功能障碍,特别是甲状腺功能障碍,与轻度认知障碍或痴呆症患者的认知状况恶化和神经精神病症状增加有关. 早期甲状腺评估对于管理这些疾病至关重要.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
背景情况:
- 甲状腺功能障碍很常见,并可能影响认知功能.
- 神经精神症状 (NPS) 在轻度认知障碍 (MCI) 或痴呆症患者中很普遍.
- 甲状腺状况与认知障碍中的NPS之间的关系尚未得到充分证实.
研究的目的:
- 研究MCI或痴呆症患者的甲状腺功能,认知状态和NPS之间的关联.
- 为了确定甲状腺功能障碍是否影响认知障碍和相关行为症状的呈现或严重程度.
主要方法:
- 对2289名新诊断出MCI或痴呆症的患者进行了横截面分析.
- 根据甲状腺刺激激素和自由甲状腺素水平,患者被分为甲状腺素,甲状腺功能低下或甲状腺功能过高的组.
- 使用多变量逻辑和线性回归来评估甲状腺功能与NPSs/认知状态之间的关联.
主要成果:
- 在甲状腺功能组之间发现了认知得分 (CDRSOB,CASI) 的显著差异.
- 甲状腺功能障碍与更高的错觉,兴奋和幻觉的几率有关.
- 甲状腺功能增高患者的整体功能 (CDRSOB) 与甲状腺功能良好患者相比较差,即使经过调整.
结论:
- 这项研究是首次评估认知障碍患者的甲状腺功能状态中痴呆症 (BPSD) 的行为和心理症状.
- 甲状腺功能障碍与较差的全球认知功能和较高的特定NPSs发病率有关.
- 在患有认知障碍和BPSD的患者中,对甲状腺状况的临床评估很重要.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
8.2K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
8.2K
Language and Cognition
836
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
836
Negative and Cognitive Symptoms of Schizophrenia
708
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
708
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
686
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
686
Alzheimer's Disease: Overview
1.8K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.8K
Functions of Thyroid Hormones
5.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.8K


