悖论性皮肤反应:在棕植物芽症中,secukinumab相关的PLEVA
Waner Liu1, Yuan Chen2, Zhimin Lin3
1Department of Dermatology, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University), Shenzhen, 518020, People's Republic of China.
Journal of inflammation research
|February 19, 2026
概括
棕植物性 pustulosis (PPP) 患者可能会发生矛盾的皮肤反应,如pityriasis lichenoides et varioliformis acuta (PLEVA) 当用IL-17抑制剂治疗时. 托法西提尼布是一种JAK抑制剂,在报告的一例病例中有效治疗了这两种疾病.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 棕植物 pustulosis (PPP) 是一种慢性炎症性皮肤疾病.
- 干白素-17 (IL-17) 抑制剂,如seukinumab,是PPP的常见治疗方法.
- 对生物疗法的皮肤矛盾反应是一个新兴的问题.
研究的目的:
- 报告一个患有PPP的患者患上皮病 lichenoides et varioliformis acuta (PLEVA) 作为对IL-17抑制的悖论性反应.
- 评估Janus激酶 (JAK) 抑制剂在控制PPP和矛盾的PLEVA中的有效性.
主要方法:
- 一名25岁的PPP女性患者接受了secukinumab的治疗.
- 患者出现了急性PLEVA喷发,由活检证实.
- 治疗被切换为托法西提尼布 (一种JAK抑制剂).
主要成果:
- 患者经历了一种矛盾的皮肤反应,在六周的sequinumab治疗后表现为急性PLEVA.
- 切换到托法西提尼布导致了原始PPP和矛盾的PLEVA爆发的显著改善.
- 活检证实了PLEVA.的诊断.
结论:
- 皮病 lichenoides et varioliformis acuta (PLEVA) 可能是IL-17抑制疗法的罕见悖论性反应.
- 氏激酶 (JAK) 抑制剂,如托法西替尼 (tofacitinib),对于经历了这种矛盾反应的患者来说,可能是有效的治疗替代品.
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