巨细胞缺氧信号通路及其在败血症中的作用
Mu Yuan1,2, Lixing Tian1,2, Xiang Xu1,2,3
1Department of Stem Cell and Regenerative Medicine, National Key Laboratory of Trauma and Chemical Poisoning, Army Characteristic Medical Center, Army Medical University, Yuzhong District, Chongqing, 400042, People's Republic of China.
Journal of inflammation research
|February 19, 2026
概括
败血症涉及巨细胞和缺氧诱导因子1-alpha (HIF-1α). 本综述探讨了HIF-1α调节途径如何影响巨细胞功能和败血症进展,并确定了潜在的治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 病理生理学 病理生理学
背景情况:
- 败血症是一种关键的系统性炎症状况,其中巨细胞是关键参与者.
- 缺氧及其信号通路,特别是HIF-1α,越来越多地被认为是它们在调节巨细胞炎症反应和代谢状态方面的作用.
研究的目的:
- 审查当前对缺氧信号通路的理解,以及它们对败血症中巨细胞功能的影响.
- 阐明HIF-1α介导的代谢重编程和在败血症相关的巨细胞中炎症酶激活的机制.
- 基于分子机制,确定潜在的治疗点和精确败血症治疗的策略.
主要方法:
- 文献综述侧重于分子信号通路,代谢重编程和毒性炎症酶激活.
- 整合来自单细胞转录组学和分子机制研究的最新发现.
- 系统地探索与低氧相关的信号效应对巨细胞功能和败血症病理.
主要成果:
- 在败血症期间,HIF-1α显著影响巨细胞代谢途径和炎症反应.
- 缺氧信号影响着巨细胞中的炎酶激活和细胞重编程,影响毒症的进展.
- 详细介绍了将缺氧,巨细胞功能和败血症病源联系在一起的特定分子机制.
结论:
- 了解巨细胞中HIF-1α驱动的通路对于败血症的发病过程至关重要.
- 准与缺氧相关的信号通路为败血症管理提供了有前途的治疗途径.
- 本综述为开发基于巨细胞中心分子机制的毒症精确干预措施提供了基础.
相关概念视频
01:24Regulation of Angiogenesis and Blood Supply
3.7K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.7K
02:53Adaptive Mechanisms in Cancer Cells
7.2K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.2K
01:23Hypoxia
2.3K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
2.3K
01:20The JAK-STAT Signaling Pathway
13.2K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
13.2K
01:21Acute Respiratory Failure-II
1.2K
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.2K
01:19Interactions Between Signaling Pathways
7.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.4K