支气管镜ROSE的样本充分性:实验室专家和病理学家之间的比较
Gergő Szűcs1, Judit Pápay2, Eszter Regős2
1Department of Pulmonology, Semmelweis University, Budapest, Hungary.
Pathology oncology research : POR
|February 19, 2026
概括
临床生物化学家可以有效地对支气管镜样本进行快速现场评估 (ROSE),并与细胞病理学家达成高度一致. 这种方法为病理学服务的资源限制提供了可行的解决方案.
科学领域:
- 肺部病理学 肺部病理学
- 细胞病理学 细胞病理学
- 临床生物化学 临床生物化学
背景情况:
- 支气管镜检查期间的快速现场评估 (ROSE) 对于评估样本的充分性和及时诊断至关重要.
- 传统上,细胞病理学家执行ROSE,但由于资源限制,这并不总是可行的.
- 这项研究探讨了临床生物化学家在大学机构执行ROSE的作用.
研究的目的:
- 为了比较由实验室专家 (临床生物化学家) 与细胞病理学家进行的ROSE评估的有效性.
- 评估由两位专业人员评估的ROSE涂抹的协议和诊断性能.
- 确定实验室专家是否可以作为ROSE的可行替代品.
主要方法:
- 78个淋巴结样本的回顾性分析,通过内支气管超声波引导的跨支气管针吸收 (EBUS-TBNA) 和跨支气管针吸收 (TBNA) 获得.
- 涂抹被临床生物化学家 (实验室专家) 和病理学家团队同时评估.
- 使用Cohen的kappa和Gwet的AC1统计数据来测量协议.
主要成果:
- 在实验室专家和病理学家团队之间观察到高达92.3%的一致率.
- 科恩的卡帕值为0.71 (强烈同意),格韦特的AC1为0.90 (几乎完全同意).
- 这两种方法都显示出出色的诊断性能.
结论:
- 由实验室专家进行的快速现场评估是对细胞病理学家评估的合适和可靠的替代方案.
- 这种方法可以帮助缓解干预性肺病学家和细胞病理学家的短缺.
- 利用临床生物化学家进行ROSE可以提高支气管镜检查期间诊断程序的效率和可访问性.
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