甲状腺刺激激素的早期产后变化以及早产婴儿随后的神经发育
Myoung-Jin Yoo1,2, Yong Hun Jang1, Gang-Yi Lee3
1Department of Pediatrics, Hanyang University College of Medicine, Seoul, Republic of Korea.
Frontiers in endocrinology
|February 19, 2026
概括
早产婴儿的甲状腺激素水平与神经发育结果有关. 持续低或下降的甲状腺刺激激素 (TSH) 水平与两岁时神经发育障碍的风险较低相关.
科学领域:
- 新生儿医学 新生儿医学
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
背景情况:
- 甲状腺激素对于胎儿大脑发育至关重要.
- 过早出生的婴儿通常具有不成熟的下丘脑-垂体-甲状腺 (HPT) 轴,导致甲状腺功能障碍.
- 过早出生婴儿的非典型甲状腺模式与神经发育风险有关.
研究的目的:
- 调查早产婴儿的甲状腺激素轨迹是否能预测两岁时的神经发育结果.
- 使用扩散张力成像 (DTI) 探索这些甲状腺模式的神经相关性.
主要方法:
- 对222名早产婴儿 (孕期≤32周) 的前性队列研究.
- 系列甲状腺功能测试 (TSH) 在1-2周和相当年龄/出院.
- 神经发育评估 (BSID-III) 和DTI在两岁时进行了校正.
- 逻辑回归与治疗权重的逆概率分析TSH轨迹和神经发育障碍 (NDI).
主要成果:
- 患有NDI的婴儿在出生时具有更高的TSH和高峰住院水平.
- 截面TSH四分位数不能独立预测NDI.
- 持续低或下降的TSH轨迹与NDI (OR 0.24-0.23) 的几率明显降低.
- 在新生儿TSH较高的婴儿中观察到前边缘区域的大脑网络中心性的改变.
结论:
- 在早产婴儿中持续低或下降的TSH轨迹与神经发育障碍的几率降低有关.
- 改变甲状腺功能和HPT轴适应可能导致异常的大脑连接和神经发育结果.
- 序列TSH监测可以帮助描述风险,并为早产婴儿的临床管理提供信息.
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