在荷尔蒙避孕药使用者和月经周期阶段的嗅觉感知和幸福感
Patrícia Maria Rodrigues Gonçalves1, Bruna Cestari de Azevedo1, Denilson Fomin1
1Hospital Israelita Albert Einstein, São Paulo, Brazil.
Frontiers in human neuroscience
|February 19, 2026
概括
口服避孕药 (OC) 的使用没有显著改变女性的整体嗅觉功能. 然而,特定的OC配方和持续使用与嗅觉性能有关,这也与主观福祉相关.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 感官科学 感官科学
背景情况:
- 荷尔蒙的波动会影响嗅觉感知.
- 口服避孕药 (OC) 使用对嗅觉的具体影响尚不清楚.
- 现有的研究往往忽视了荷尔蒙避孕和情绪健康之间的相互作用.
研究的目的:
- 调查口服避孕药 (OC) 使用对女性嗅觉功能的影响.
- 根据OC配方和治疗方案,探索嗅觉功能的差异.
- 研究OC使用者和非使用者的嗅觉性能和主观幸福之间的关系.
主要方法:
- 使用Sniffin' Sticks测试来评估98名女性的嗅觉值,歧视和识别 (OC用户和自然骑自行车的对照).
- 评估参与者在标准化时间点对应激素阶段 (半排卵期,黄体期,活性/无活性药丸周期).
- 收集了关于生活满意度和主观幸福感的自我报告数据,以与嗅觉功能相关联.
主要成果:
- 在OC使用者和非使用者之间没有观察到嗅觉表现的重大整体差异.
- 探索性分析表明,基于雌二醇烯酸的OC与较高的嗅觉得分 (门值,TDI) 之间存在潜在联系,尽管样本规模有限 (n=4).
- 仅含孕激素的配方,连续使用OC和使用OC的更长时间与较低的嗅觉敏感性 (门) 有关.
- 在OC (n=47) 和非OC (n=51) 组中,更好的嗅觉表现与更高的主观幸福感正相关.
结论:
- 口服避孕药的配方,方案和持续时间可能会影响嗅觉处理的可变性.
- 情绪状态,特别是主观幸福感,与嗅觉表现有关,不论OC使用情况如何.
- 这些发现突显了荷尔蒙避孕,感官功能和情绪健康之间的未被充分研究的关联,需要进一步研究.
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