铁补充剂对儿童认知发育的影响:总体综述
Luz Marina Caballero-Apaza1, Heber Isac Arbildo-Vega2,3,4, Vilma Mamani-Cori5
1Department of Nursing, School of Nursing, Universidad Nacional del Altiplano, Puno, Peru.
Frontiers in nutrition
|February 19, 2026
概括
补充铁对贫血儿童提供了适度的认知益处,改善了智力和注意力. 然而,在非缺铁儿童中,益处是可以忽略不计的,这凸显了有针对性的铁干预措施的必要性.
科学领域:
- 儿童营养学 儿童营养学
- 认知神经科学 认知神经科学
- 证据综合 证据综合
背景情况:
- 缺铁是影响儿童发育的全球性问题.
- 认知发展对营养状况,特别是铁含量敏感.
- 系统审查和元分析对于综合干预证据至关重要.
研究的目的:
- 综合和批判评估现有的系统审查和元分析.
- 评估补充铁对儿童认知发育的影响.
- 评估相关审查中的质量和偏见风险.
主要方法:
- 在多个数据库 (PubMed,Cochrane,Scopus,Web of Science,Embase) 和灰色文献中进行全面的文献搜索.
- 包括有或没有对补充铁和儿童认知进行元分析的系统性审查.
- 使用AMSTAR-2进行方法质量评估,使用ROBIS进行偏差风险评估,使用CCA进行重叠分析.
主要成果:
- 包括17个系统审查,其中3个被评为高可信度和偏差风险低.
- 铁补充剂在贫血儿童中显示出适度的认知效益 (智力,记忆,注意力).
- 在非缺陷儿童中,影响是可以忽略的或不确定的,在更广泛的心理发展或学业成绩方面没有持续的改善.
结论:
- 高可信度证据支持向补充铁对贫血儿童的认知益处.
- 目前的证据不支持在非缺铁儿童中普遍补充铁.
- 未来的研究应该专注于更同质的试验,以澄清长期的认知结果.
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