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慢性压力相关的杏仁体代谢活动与结直肠癌中远程转移之间的关联

Hyun Joo Kim¹, Sejin Ha², Chanmin Joung³

¹Department of Nuclear Medicine, Korea University College of Medicine, Seoul, Republic of Korea.

Frontiers in endocrinology

|February 19, 2026

概括

杏仁体代谢活动升高,这是慢性压力的标志物,与结直肠癌 (CRC) 患者的远程转移有关. 这一发现表明,杏仁体活动可能是CRC风险分层的新型成像生物标志物.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
神经科学是一个神经科学.

背景情况:

慢性压力通过神经内分泌和炎症途径影响癌症的进展.
杏仁体的代谢活动,可通过18F-FDG PET/CT测量,可能表明慢性压力.
慢性压力在结直肠癌 (CRC) 转移中的作用尚未完全理解.

研究的目的:

研究桃体代谢活性 (AmygA) 升高与CRC患者远程转移之间的关联.
确定AmygA是否可以作为成像生物标志物用于预测CRC转移.

主要方法:

包括76名新诊断的CRC患者,他们接受了18F-FDG PET/CT和手术的预治疗.
AmygA被定义为杏仁体SUVmax与边叶SUVmean的比值.
使用ROC分析来找到最佳的AmygA值用于转移预测和独立预测因子的后勤回归.

主要成果:

在27.6%的患者中存在远程转移.
在患有远程转移的患者中,AmygA显著更高 (1.17 ± 0.06 与 1.08 ± 0.06; p < 0.001).
1.159的AmygA切线预测了远程转移,具有71.4%的灵敏度和89.1%的特异性 (AUC = 0.844;p < 0.001).
在多变量分析中,AmygA升高与远程转移独立相关.

结论:

在18F-FDG PET/CT上桃体代谢活性升高是CRC中远程转移的独立预测因子.
AmygA可能作为CRC风险分层的新型成像生物标志物起作用.
这一发现为癌症转移中与压力相关的神经机制提供了洞察力.

关键词:

阿米格达拉的桃体结肠直肠癌是什么意思转移转移转移转移定子发射断层扫描 (PET).压力就是压力,压力就是压力.

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