短期与一夜间授精:对于在试管婴儿周期中只获得一两个卵细胞的患者来说,哪个更好?
Jinghua Chen1, Zhenfang Liu1, Jiali Cai1,2
1Reproductive Medicine Center, Xiamen University Affiliated Chenggong Hospital, Xiamen, Fujian, China.
Frontiers in endocrinology
|February 19, 2026
概括
在受精反应较差且卵子数量有限的患者中,短期授精不会对累积活产率产生负面影响. 这种方法可能对接受扩展胚胎培养到囊胚阶段的患者有好处.
科学领域:
- 生殖医学 生殖医学
- 在体外受精 (IVF)
背景情况:
- 与一夜间方法相比,在响应较差的患者中,短期授精的有效性存在不确定性.
- 在这种情况下,很少有研究评估累积活产率 (CLBR) 作为主要终点.
研究的目的:
- 为了比较短期 (5小时) 与一夜之间 (17小时) 的受精在1-2个卵细胞的低响应者中.
- 评估对累积活产率的影响.
主要方法:
- 对2392次试管婴儿周期的回顾性分析.
- 根据化时间,分为短期和一夜间授精组.
- 倾向性得分与混变量的控制匹配.
主要成果:
- 短期授精产生了更多正常受精的胚胎 (P < 0.05).
- 在匹配前或之后,两组之间的CLBR没有显著差异 (P > 0.05).
- 在接受扩展胚胎培养的子组中观察到对CLBR的潜在益处.
结论:
- 短期授精对有有限卵子细胞的响应较差的患者的CLBR没有不利影响.
- 扩展胚胎培养到囊胚阶段可能有利于短期授精以改善结果.
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