素补充剂对运动诱导的氧化应激的影响:随机对照试验的系统审查和元分析
Ting You1, Kejia Peng2,3, Kai Zhao1
1Beijing Sport University, Beijing, 100084 China.
3 Biotech
|February 19, 2026
概括
阿斯塔丁补充剂可能会降低运动诱导的蛋白质氧化,这是通过降低先进氧化蛋白产品 (AOPP) 表明的. 然而,氧化应激和性能益处的其他标志物仍然不清楚,需要进一步研究.
科学领域:
- 运动生理学 运动生理学
- 营养生物化学 营养生物化学
- 生物标志物研究 生物标志物研究
背景情况:
- 作为一种强有力的抗氧化剂,阿斯丁在减少氧化应激方面表现有前途.
- 临床证据表明,阿斯塔山丁在减轻人类运动诱导的氧化压力的有效性是不一致的.
- 高级氧化蛋白产品 (AOPP) 提供了对蛋白质氧化损伤的敏感测量.
研究的目的:
- 进行元分析随机对照试验 (RCT),评估阿斯塔山丁对运动诱导的氧化应激的影响.
- 作为一个关键生物标志物,研究阿斯塔克桑对先进氧化蛋白产品 (AOPP) 的作用.
- 综合目前关于阿斯塔克桑在人类氧化应激反应中的作用的证据.
主要方法:
- 一个系统的RCT的分析发表到2025年8月.
- 包括涉及4天至12周的阿斯塔山丁补充剂 (4-28毫克/天) 的试验.
- 采用随机效应模型,并进行异质性和灵敏性分析,将标准化平均差异 (SMD) 汇集在一起.
主要成果:
- 包括7个RCT和188名参与者.
- 阿斯丁显著降低了AOPP水平 (SMD = -1.06;95% CI: -1.49至 -0.62),表明蛋白质氧化减少.
- 在其他生物标志物如MDA/TBARS,SOD,SH,CK或IL-6中没有发现显著变化.
结论:
- 阿斯坦丁补充剂似乎减弱了蛋白质的氧化,可能是通过抗氧化机制.
- 阿斯塔克桑的更广泛的生理或提高绩效的益处需要进一步研究.
- 需要使用标准化方案进行更大,更长时间的RCT来确认临床相关性.
更多相关视频
08:16Method for the Assessment of Effects of a Range of Wavelengths and Intensities of Red/near-infrared Light Therapy on Oxidative Stress In Vitro
Published on: March 21, 2015
9.2K
09:33Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
Published on: February 7, 2018
7.9K
相关概念视频
Exercise and Cardiovascular Response
4.7K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
4.7K
Exercise Stress Test
1.5K
Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
1.5K
Exercise and Cardiac Output
2.2K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
2.2K
Atherosclerosis III: Management
465
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
465
