来自Pithecellobium dulce的异形选择性AKT抑制剂的药基因组学和体鉴定,用于精确的癌症治疗

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Gnanaprakash Jeyaraj1, Bing Yang2, Kuppusamy Sathishkumar3

  • 1Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.

Frontiers in pharmacology
|February 19, 2026
PubMed
概括

这项研究确定了来自Pithecellobium dulce的天然化合物烯酸和鲁丁,这些化合物分别有选择性地准AKT1和AKT2激酶. 这些发现为开发针对PI3K-AKT-mTOR通路的新精密瘤治疗提供了基础.

关键词:
抑制了AKT1/AKT2的发生.皮特塞洛比乌姆 (Pithecellobium dulce) 是一种甜美的植物.异形选择性是异形选择性的.分子动力学分子动力学自然产品药物发现自然产品药物发现

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