雷米马佐拉姆对接受甲状腺手术的患者手术后咳的影响:一项随机双盲对照临床试验
Xianchun Liu1, Ting Zhang1, Li Zhao1
1Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Nanchong Branch, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, People's Republic of China.
Drug design, development and therapy
|February 19, 2026
概括
在甲状腺手术患者中,雷米马佐拉姆显著减少了从全身麻醉中出现的咳. 这种麻醉剂在这种手术患者群体中为控制呼吸道反射提供了一个有前途的选择.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 手术患者护理手术患者护理
背景情况:
- 在麻醉后出现咳可能会导致并发症.
- 甲状腺手术患者容易发生与呼吸道相关的不良事件.
- 优化麻醉的出现对于患者的安全和康复至关重要.
研究的目的:
- 评估雷米马佐拉姆在一般麻醉的出现阶段抑制咳的疗效.
- 在接受甲状腺手术的患者中,比较雷米马佐拉姆和盐水组之间咳的发生率和严重程度.
主要方法:
- 一项随机对照试验,涉及68名接受甲状腺手术的患者.
- 患者在麻醉维持期间接受了雷米马佐拉姆输液或盐水作为对照.
- 评估了咳发生率,严重程度,唤醒时间,输出管时间和血液动力学参数.
主要成果:
- 与对照组相比,雷米马佐拉姆显著降低了咳的发生率 (38.24%vs. 76.47%).
- 中度至重度咳的频率和整体咳的严重程度在雷米马佐拉姆组较低.
- 虽然唤醒和输出时间延长了,但镇静得分增加了,群体之间没有显著的血液动力学差异.
结论:
- 在接受甲状腺手术的患者中,雷米马佐拉姆有效地抑制了全身麻醉后出现的咳.
- 雷米马佐拉姆的使用可以通过减轻呼吸道反射来改善出现的情况.
- 进一步的研究可以探索最佳的剂量和患者选择在手术环境中使用雷米马佐拉姆.
更多相关视频
相关概念视频
Sedatives and Hypnotics Drugs: Miscellaneous Agents
636
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
636
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
1.2K
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
1.2K
Sedatives and Hypnotics: Overview
1.6K
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
1.6K
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
719
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
719
General Anesthesia: Overview
756
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
756
Tonsillitis II: Management
453
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
453


