在关节骨关节炎中可代因与氧化的精神病,心血管和骨风险:基于人口的队列研究
Jeongmin Lee1,2,3, Yujin Kim1,2,3, Eunjung Choo4
1Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul, Korea.
Drug design, development and therapy
|February 19, 2026
概括
与 oxycodone 相比,在关节骨关节炎患者中使用编解会增加精神疾病和骨折风险. 个性化处方至关重要,考虑到患者因素和对不良事件的监测.
科学领域:
- 整形外科 整形外科 整形外科
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 关节骨关节炎 (OA) 在老年人群中引起慢性疼痛和残疾.
- 阿片类药物经常被处方用于关节OA疼痛,但比较安全性数据有限.
- 这项研究解决了在关节OA中对可代因与氧化的比较安全数据的需求.
研究的目的:
- 为了比较可代因和氧可使用者与部OA之间的精神病,心血管和骨结果.
- 在关节OA管理中识别与可代因和氧可相关的差异性风险.
- 为部OA提供个人化阿片类药物处方策略的信息.
主要方法:
- 基于人口的回顾性队列研究,使用韩国HIRA索赔数据.
- 包括关节骨关节炎患者开始使用编解或氧化,并进行倾向得分匹配 (PSM) 和IPTW灵敏度分析.
- 评估结果包括精神疾病,主要不良心血管事件 (MACE) 和骨折,使用Cox比例危险模型进行分析.
主要成果:
- 胆固醇使用与患精神疾病,特别是焦虑和睡眠障碍的风险更高有关 (HR 1.11,95% CI 1.04-1.19).
- 代代因还与非骨骨折的风险增加有关 (HR 1.10,95% CI 1.04-1.16).
- 对于MACE和死亡的风险在可代因和氧可组之间是可比的.
结论:
- 关节骨关节炎患者使用代代因与精神疾病和特定骨折类型的风险增加有关.
- 观察到的风险因患者特征,并发症和同时服用的药物而异.
- 个性化阿片类药物处方,包括精神病监测和骨折风险评估,对于关节OA管理至关重要.
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