在骨科手术中通过药物诱导测试证实了对特兰胺酸的意外过敏反应:一个病例报告
Seung Eun Song1, Ae-Ryoung Lee1
1Department of Anesthesiology and Pain Medicine, Jeju National University College of Medicine, Jeju, Republic of Korea.
Saudi journal of anaesthesia
|February 19, 2026
概括
在整形外科手术期间,TXA的严重过敏反应可能会发生. 及时识别和治疗,包括上腺素,对于控制这种罕见但严重的不良反应至关重要.
科学领域:
- 麻醉学 麻醉学
- 过敏和免疫学 过敏和免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 特兰胺酸 (TXA) 在骨科手术中被广泛使用,以最大限度地减少血液损失.
- 虽然TXA通常是安全的,但很少会引发严重的过敏反应.
- 外科手术期间的过敏反应带来了诊断挑战,特别是在全身麻醉下.
研究的目的:
- 在静脉注射TXA后报告严重过敏反应的病例.
- 要突出诊断困难和管理策略的外科手术期间过敏反应.
- 强调对疑似TXA过敏性进行确认测试的重要性.
主要方法:
- 一个33岁的男性在TXA后出现过敏反应的病例报告.
- 临床评估包括支气管,低血压和心律不整.
- 诊断工作包括血清三酶,皮肤刺伤测试 (SPT) 和静脉药物诱导测试 (DPT).
主要成果:
- 在TXA输注后不久,患者出现了严重的过敏反应症状.
- 最初的血清试酶是正常的;SPT显示微量阳性.
- DPT证实IgE介导的过敏对TXA在100毫克,重现症状.
结论:
- 严重的过敏反应是一种罕见但关键的风险,与静脉TXA相关.
- 早期识别和及时给予上腺素对于患者的生存至关重要.
- 像DPT这样的确认性测试对于诊断IgE介导的TXA过敏至关重要.
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