牛乳杆菌 (Lactobacillus murinus) 通过促进氨酸生产来缓解高果糖诱导的MASLD
Xinglin Mo1,2,3, Guilin Zhao1,2,3, Lanlan Liu4
1Hepatobiliary Surgery Department Guangxi Medical University Cancer Hospital Nanning Guangxi China.
Food science & nutrition
|February 19, 2026
概括
高果糖饮食导致与代谢功能障碍相关的脂肪性肝病 (MASLD) 通过减少肠道Lactobacillus murinus. 补充L. murinus或阿金宁可以缓解MASLD症状和肝损伤.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 高果糖饮食与代谢功能障碍相关的脂肪性肝病 (MASLD) 的增加有关.
- 果糖影响肠道微生物群并导致MASLD的确切机制尚未完全理解.
研究的目的:
- 为了研究果糖对肠道微生物群组成的影响.
- 阐明乳糖菌 (L. murinus) 在果糖诱导的MASLD中的作用.
- 探索L. murinus和阿基尼因作为MASLD的潜在治疗点.
主要方法:
- 使用高果糖暴露 (饮用水和饮食) 的小鼠模型.
- 使用16S rDNA测序分析了肠道微生物群.
- 服用L. murinus和氨酸补充剂.
- 进行了血清和便代谢分析和ELISA.
主要成果:
- 果糖显著降低了小鼠中的L. murinus丰富度.
- 补充L. murinus减轻了MASLD,减少了肝炎,气球和脂质积累.
- L. murinus恢复了氨酸水平,氨酸补充剂模仿了其治疗效果.
结论:
- 果糖诱导的MASLD涉及肠道L. murinus的减少,破坏了阿尔金因代谢.
- L. murinus和氨酸代表了管理果糖诱导的MASLD的有前途的治疗策略.
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