聚菌炎和皮肤菌炎中血清中介素-38水平升高:诊断含义和与炎症标志物的相关性
1Department of Rheumatology and Immunology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Frontiers in immunology
|February 19, 2026
概括
血清中介质素 (IL) -38水平在多聚菌炎 (PM) 和皮肤菌炎 (DM) 患者中升高. 升高的IL-38与疾病标志物相关,并显示出这些炎症性肌肉病的诊断潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 互乐金 (IL) -38是一种已识别的抗炎细胞因子.
- 聚髓炎 (PM) 和皮肤肌肉炎 (DM) 是常见的炎症性肌肉病变.
研究的目的:
- 在PM/DM患者中研究血清IL-38度.
- 评估IL-38与PM/DM的相关性.
主要方法:
- 在77名PM/DM患者和40名对照中使用酶相关的免疫吸收试验量化血清IL-38.
- 通过接收器运行特征曲线分析评估IL-38的诊断效用.
主要成果:
- 血清IL-38在PM/DM患者和对照人群中显著升高.
- IL-38与视觉模拟尺度,乳酸脱酶 (LDH) 和炎症标志物正相关.
- 单独或与LDH一起,IL-38显示出显著的诊断潜力.
结论:
- 在PM/DM患者中血清IL-38升高与LDH水平相关.
- IL-38可能调节PM/DM中的炎症反应.
- IL-38是PM/DM的潜在指标.
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