慢性子宫内膜炎对辅助生殖技术结果的影响:一个倾向得分逆概率加权队列研究
Wenjie Huang1,2,3, Liqiong Duan2,3, Liuyan Wei2,3
1Reproductive Genetics Department / Obstetrics Department, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Frontiers in cell and developmental biology
|February 19, 2026
概括
通过CD138+血细胞诊断慢性子宫内膜炎 (CE) 并没有影响辅助生殖技术 (ART) 中的活产或怀孕率. 对CE的抗生素治疗也没有显著的益处,这表明可能不需要进行常规查.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 妇科病理学 妇科病理学
- 不孕症研究 不孕症研究
背景情况:
- 慢性子宫内膜炎 (CE),通过CD138+血细胞透来确定,被怀疑会对辅助生殖技术 (ART) 的结果产生负面影响.
- 目前关于CE对生殖成功的影响的证据不一致,诊断标准各异.
- 这项研究调查了CE诊断和抗生素治疗对IVF-ET和FET周期中的怀孕和活产率的影响.
研究的目的:
- 评估慢性子宫内膜炎 (CE) 诊断与辅助生殖技术 (ART) 结果之间的关联.
- 评估抗生素治疗CE在改善怀孕和活产率方面的疗效.
- 确定所有ART候选人的CE查是否有必要.
主要方法:
- 从1,401名不育妇女 (2008-2023) 中对3,041个胚胎移植周期 (IVF-ET和FET) 的回顾性分析.
- CE定义为每10个高功率场 (HPF) 的≥1个CD138+血细胞.
- 使用Poisson回归分析的结果具有强大的标准误差和倾向得分加权.
主要成果:
- 在IVF-ET和FET中,CE和非CE患者之间的活产或临床怀孕率没有显著差异.
- 与IVF-ET或FET周期中没有治疗相比,对CE的抗生素治疗没有改善结果.
- 在IVF-ET后,CE患者的流产风险较低 (aRR为0.67).
结论:
- CD138+血细胞定义慢性子宫内膜炎 (CE) 与ART的妊娠或活产率降低无关.
- 对CE的抗生素治疗在改善ART结果方面没有显示出统计学上显著的益处.
- 常规CE查可能是不必要的;建议对高危子组进行进一步的研究.
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