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Updated: Feb 20, 2026

Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography
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结构-活动关系研究,以优化GPCRRRelaxin/胰岛素类家族受体2的第一级选择性小分子激动剂

Kenneth J Wilson1, Maria Esteban-Lopez2, Courtney Myhr2

  • 1National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States.

Journal of medicinal chemistry
|February 19, 2026
PubMed
概括

研究人员确定了一种新型小分子,化合物68,作为Relaxin/胰岛素类家族受体2 (RXFP2) 的第一个完整的agonist. 这种强效化合物对研究各种生理系统中的RXFP2激活具有前景.

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