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Updated: Feb 20, 2026

Extracting the Young's Modulus of Native Murine Pulmonary Basement Membranes from Atomic Force Microscopy Derived Force Maps
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细胞外矩阵刚性作为早期骨关节炎的关键分子事件:RhoA/ROCK和ERK1/2通路之间的交叉

Kai Huang1, Haili Cai2, Yifan Hong3

  • 1Tongde Hospital of Zhejiang Province, Hangzhou, China.

The American journal of sports medicine
|February 19, 2026
PubMed
概括

骨关节炎的细胞外基质 (ECM) 硬会激活RhoA/ROCK信号,然后激活ERK1/2信号,促进软骨的退化. SPRY-4调节了这种途径,为早期OA提供了潜在的治疗点.

关键词:
在ERK1/2中.罗亚/罗克 (ROCK) 是一个这就是SPRY-4的原因.冠状腺细胞 (chondrocytes) 是一种体内细胞.细胞外矩阵刚度 细胞外矩阵刚度骨关节炎是一种关节炎.

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