在健康的年轻人中,与夏季相比,冬季皮肤微血管功能降低
James F Bangle1, William E Jennings1, Alyssa J Guadagni1
1Department of Kinesiology, University of Georgia, Athens, Georgia, USA.
Physiological reports
|February 19, 2026
概括
在冬季,健康的成年人由于温度降低和紫外线辐射 (UVR) 暴露,皮肤血管功能减弱. 这种季节性变化会影响氧化介导的血管扩张,影响皮肤微血管反应.
科学领域:
- 生理学 生理学 生理学
- 环境健康 环境健康
- 皮肤病学 皮肤病学
背景情况:
- 皮肤微血管内皮功能依赖于氧化 (NO) 介导的血管扩张.
- 温度和紫外线 (UVR) 暴露的季节性变化可能会影响NO介导的血管扩张.
- 了解这些季节性影响对于评估全年皮肤健康和血管功能至关重要.
研究的目的:
- 评估健康成年人的皮肤微血管内皮功能季节性变化.
- 研究环境因素 (温度,紫外线) 与NO介导血管扩张之间的关系.
- 为了确定季节对皮肤微血管反应的影响.
主要方法:
- 10名健康成年人参加了两次实验性访问,间隔约6个月 (夏季/初秋和冬季/初春).
- 用皮肤内微透析和局部皮肤加热 (42°C) 来评估皮肤微血管内皮质功能.
- 在每次访问之前,记录/测量了环境数据 (日间平均温度,高峰紫外线指数) 和血清维生素D [25(OH) D].
主要成果:
- 与夏季/初秋季相比,冬季/初春季的局部皮肤加热反应和NO贡献明显较低.
- 多变量回归表明,30天的室外平均温度和峰值紫外线指数分别与NO依赖血管扩张有积极和消极的关联.
- 维生素D水平在最佳适应模型中并不是显著因素.
结论:
- 健康的成年人在冬季/早春期间与夏季/早秋期间相比,NO介导的皮肤血管扩张减少.
- 室外温度和紫外线暴露的季节性差异部分解释了这些观察到的皮肤微血管功能的变化.
- 这些发现强调了对血管健康的环境影响,并表明了季节性皮肤生理学的潜在影响.
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