预防动脉样硬化心血管疾病在年轻男性雄激素滥用者
Peter Bond1, Diederik L Smit1,2, Tijs Verdegaal1,3
1Department of Performance and Image-Enhancing Drugs Research, Android Health Clinic, Utrecht, the Netherlands.
Clinical cardiology
|February 19, 2026
概括
年轻男性的雄激素滥用显著增加了动脉样硬化心血管疾病 (ASCVD) 的风险,通过对血压和脂质概况产生负面影响. 传统的风险计算器可能会低估这种危险,需要个性化预防策略.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 雄激素滥用在年轻男性中越来越令人担忧,造成动脉样硬化心血管疾病 (ASCVD) 的未被认可的风险.
- 超生理性雄激素暴露通过影响脂蛋白概况,血压和血管功能,可能加速动脉样硬化,对心血管健康产生负面影响.
- 标准心血管风险预测模型可能低估了ASCVD风险在这个人群中由于独特的因素,如波动的生物标志物.
研究的目的:
- 探索将雄激素滥用与ASCVD联系在一起的机制.
- 为了确定常规风险分层工具对雄激素滥用者的局限性.
- 在这个人口群体中建议个性化的风险评估和预防方法.
主要方法:
- 进行了叙事审查.
- 该综述综合了从流行病学,成像学和机械学研究中得出的发现.
- 研究集中在滥用雄激素的人的心血管风险因素和亚临床动脉样硬化.
主要成果:
- 证据证实,雄激素滥用会对脂质特征,血压和血管内皮功能产生不利影响.
- 滥用雄激素与较高的亚临床动脉样硬化的患病率有关.
- 传统的风险预测模型可能会低估年轻男性的ASCVD风险,原因包括年龄,波动的生物标志物和累积暴露效应等因素.
结论:
- 必须承认,雄激素滥用是年轻男性心血管风险增加的重要因素.
- 超越标准计算器的个性化心血管风险评估对于高危人群的有效预防策略至关重要.
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