心脏衰竭中的多药与心血管风险相关:系统性审查和元分析
Jane J Lee1, Minseo Kim1, Gerald Chi2
1Department of Food and Nutrition, Sookmyung Women's University, Seoul, Republic of Korea.
ESC heart failure
|February 19, 2026
概括
多药性,即多种药物的使用,增加了HF患者心血管不良事件和心力衰竭 (HF) 住院的风险. 仔细的药物审查对于优化治疗和患者的结果至关重要.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 多药在心力衰竭 (HF) 患者中很常见,原因是多种并发症和指导方针导向治疗.
- 虽然旨在优化护理,但多药可以导致药物相互作用和不良事件.
- 关于多药对高风暴患者心血管 (CV) 结果的影响的证据有限.
研究的目的:
- 为了研究多药和HF患者的不良心血管结果之间的关联.
- 在这个队列中量化与多药相关的特定CV事件的风险.
主要方法:
- 进行了系统性审查和元分析.
- 在PubMed,Embase和Web of Science进行了搜索,以确定相关的研究.
- 随机效应模型被用来组合效应估计,比较最高和最低的多药水平.
主要成果:
- 该分析包括了10项研究,其中包括30,115名HF患者.
- 多药性药物显著增加了复合心血管终点的风险 (HR:1.27;95% CI:1.15-1.39).
- 随着多种药物 (HR: 1.42; 95% CI: 1.28-1.56),观察到高风险的HF住院,但与心血管死亡或全因死亡率没有显著的关联.
结论:
- 在HF患者中,多药性与复合心血管结局和HF住院的风险更高有关.
- 这些发现突出了管理HF患者多种药物的挑战.
- 个性化药物审查对于减少不适当的处方和确保基于证据的护理至关重要.
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