醒来后第一支香烟的时间和心脏衰竭事件:来自英国生物银行的剂量反应分析
Jiahua Wen1,2, Zhaohan Yan1,2, Yue Cao1,2
1Department of Cardiology, The Eighth Affiliated Hospital, Southern Medical University (The First People's Hospital of Shunde Foshan, No. 1 Jiazi Road, Lunjiao, Shunde District, Foshan City, Guangdong Province 528308, China.
醒来后不久吸烟与心力衰竭风险增加有关. 这种关联是剂量依赖的,更快的时间到第一个香烟 (TTFC) 表明心力衰竭发病率更高.
科学领域:
- 心血管流行病学心血管流行病学
- 烟草研究 烟草研究
- 公共卫生 公共卫生
背景情况:
- 吸烟是心血管疾病的主要危险因素,包括心力衰竭 (HF).
- 吸烟的强度,通常反映在第一支香烟的时间 (TTFC),可能会影响疾病风险.
- 了解吸烟模式和HF发病率之间的关系对于预防策略至关重要.
研究的目的:
- 调查醒来后第一支香烟的时间 (TTFC) 和发生心力衰竭 (HF) 之间的关联.
- 为了确定TTFC是否是一个独立的HF风险因素,在一个大型的前性队列.
- 探索TTFC与吸烟数量和持续时间对HF风险的综合影响.
主要方法:
- 利用了英国生物银行229,391名参与者的数据.
- 根据TTFC间隔 (<5, 5-15, 30-60, 61-120, >120分钟) 对目前的吸烟者进行分类.
- 采用多变量Cox比例危险模型和联合分析来评估TTFC与HF的关系,考虑吸烟负担和持续时间.
主要成果:
- 在较短的TTFC和增加的HF风险之间观察到显著的剂量依赖关系 (趋势P<0.001).
- 与非吸烟者相比,有TTFC<5分钟的吸烟者对HF的调整危险比率 (HR2.22) 是最高的.
- 较短的TTFC与更高的HF风险有关,特别是在60岁以下的个体中.
结论:
- 第一次吸烟的时间缩短 (TTFC) 独立地与发生性心力衰竭 (HF) 的风险更高有关.
- TTFC为HF风险分层提供了宝贵的信息,超出了吸烟数量和持续时间.
- 评估TTFC可能特别有利于识别高风险的年轻人.
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