在10岁以下的儿童中,芬太尼暴露的特征
Danae Massengill1,2, Lynne Rosenberg1, Eli Forst2
1Rocky Mountain Poison and Drug Safety, Denver Health, Denver, CO, USA.
Clinical toxicology (Philadelphia, Pa.)
|February 19, 2026
概括
非法暴露于芬太尼对幼儿构成严重风险,经常导致呼吸道和中枢神经系统的抑郁. 及时识别和纳洛 (Narcan) 治疗对于管理这些儿科芬太尼暴露至关重要.
科学领域:
- 儿科毒理学 儿科毒理学
- 紧急医疗 紧急医疗
- 公共卫生 公共卫生
背景情况:
- 非法制造的芬太尼在儿童群体中越来越令人担忧.
- 关于儿童芬太尼暴露的临床过程和管理的数据有限.
- 这项研究解决了更好地了解儿科芬太尼毒性的需要.
研究的目的:
- 描述10岁以下儿童芬太尼暴露的临床特征.
- 概述这些儿科病例的管理策略和治疗结果.
- 旨在为临床实践提供信息,并改善暴露于芬太尼的儿童的患者护理.
主要方法:
- 一个单独的儿童医院的回顾性图表审查.
- 纳入标准:年龄在10岁以下,已确认暴露于芬太尼的患者 (尿液免疫检测或药物测试).
- 收集的数据:人口统计,暴露来源,症状,治疗,处置和结果.
主要成果:
- 包括25名儿童 (平均年龄为14个月).
- 大多数有症状的患者 (92%) 显示中枢神经系统抑郁,88%的呼吸系统抑郁.
- 8名患者 (31%) 需要心肺复苏;92%接受纳洛 (Narcan),许多患者需要多剂量或输液.
结论:
- 芬太尼暴露显著影响幼儿,导致严重的症状,如呼吸道和中枢神经系统的抑郁.
- 几乎所有受影响的儿童都需要纳洛 (Narcan) 和住院治疗.
- 通过芬太尼免疫检测及时检测和及时干预,包括纳洛 (Narcan) 处方,对于管理儿科芬太尼毒性至关重要.
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