带有去差异化模仿良性新生体的乐性肌肉瘤
Megan Hoang1, Fatima N Mirza2, Annie R Wang3
1Warren Alpert Medical School of Brown University, Providence, RI.
The American Journal of dermatopathology
|February 19, 2026
概括
一种罕见的表面性乳腺肌肉瘤,在一个年轻女子身上呈现异常,以移动结节的形式. 通过切除活检及时诊断对于这种具有攻击性的软组织肉瘤至关重要.
科学领域:
- 在瘤学瘤学.
- 皮肤病理学 皮肤病理学
- 软组织肉瘤 (软组织肉瘤)
背景情况:
- 表面性乳腺肌肉瘤是一种罕见的软组织肉瘤,通常影响50岁以上的成年人,具有坚固而痛苦的结节.
- 皮肤不分化的乳腺肌肉瘤是非常罕见的,之前仅有两例报告的病例,两者呈现不同.
研究的目的:
- 在一个不寻常的人口和位置报告一种独特的表面性乳腺神经瘤病例,并没有区分.
- 突出软组织肉瘤的非典型表现所带来的诊断挑战.
主要方法:
- 切除活检样本的组织病理学评估.
- 免疫组织化学染色用于光滑肌肉的动因和脱离.
- 临床相关性和现有文献的审查.
主要成果:
- 鉴定出了一种中等级的带焦脱差的乳腺肌肉瘤,表现出突然过渡到高级不分化的肉瘤.
- 免疫组织化学检查显示,在非分化区域,光滑肌肉中失去了actin和desmin.
- 患者在广泛的局部切除后实现了明显的边缘,没有转移的证据.
结论:
- 这一案例强调了在持续性皮下结核中考虑恶性瘤的重要性,即使是异常呈现.
- 早期识别和手术干预是至关重要的,因为无差异化乳腺神经瘤的攻击性和转移潜力.
- 这份报告有助于对皮肤不分化的乳腺肌肉瘤,特别是其多种临床表现的有限理解.
更多相关视频
相关概念视频
01:13Formation of Muscle Fibers from Myoblasts
5.8K
De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
5.8K
01:21Satellite Stem Cells and Muscular Dystrophy
1.7K
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
1.7K