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自组装的二覆盖银纳米粒子的双重抗菌和抗癌功能:对蛋白质-纳米粒子相互作用的分子见解

Sovan Samanta¹, Rubai Ahmed¹, Anwesha Das²

¹Department of Physiology, University of Gour Banga, Malda 732103, W.B., India.

ACS applied bio materials

|February 19, 2026

概括

自组装的功能化银纳米粒子 (SAP@AgNPs) 对抗药物耐药细菌和白血病细胞表现出强大的抗菌和抗癌活性. 这些生物相容的纳米颗粒由于它们与细胞表面蛋白的有针对性的相互作用,显示出有前途的治疗潜力.

科学领域:

纳米技术纳米技术
材料科学材料科学材料科学
生物医学工程生物医学工程

背景情况:

基于纳米粒子的药物输送系统为对抗多药耐药细菌感染和恶性细胞提供了一个有前途的治疗策略.
自组装功能化银纳米粒子 (SAP@AgNPs) 可以通过方便的自下而上的方法来合成.

研究的目的:

为潜在的治疗应用制造和描述SAP@AgNPs.
评估SAP@AgNPs的抗菌和抗癌疗效.
评估SAP@AgNPs的生物相容性和潜在机制.

主要方法:

SAP@AgNPs是使用自下而上的方法合成的,NaBH4作为减少剂.
使用UV-vis,FTIR,XPS,TEM,FE-SEM,DLS,ZETA和XRD进行了物理化学特性分析.
抗菌活性被测试在对抗多药耐药的金黄色葡萄球菌和大肠杆菌.
对K-562白血病细胞的抗癌活性进行了评估.
使用HEK-293和PBMCs评估生物相容性,并进行血液溶解试验.
使用in silico方法研究与细胞表面蛋白的相互作用.

主要成果:

SAP@AgNPs表现出对S. aureus (MBC:0.05 nM) 和大肠杆菌 (MBC:0.04 nM) 的剂量依赖的抗菌活性.
SAP@AgNPs显示出对K-562细胞具有显著的抗癌作用,IC50为0.029nM.
这些纳米颗粒显示出微不足道的血液溶解 (≤2%) 和良好的生物相容性,IC50值为0.035nM (HEK-293) 和0.155nM (PBMCs).
在分析显示,SAP@AgNPs与细菌和癌细胞的细胞表面蛋白之间存在强烈的相互作用.

结论:

SAP@AgNPs代表了一个强大的基于纳米的药物输送系统,具有显著的抗菌和抗癌特性.
观察到的生物有效性归因于ROS生成和与细胞表面蛋白质的特定相互作用.
SAP@AgNPs表现出良好的生物相容性,突出了它们对抗性感染和癌症的治疗应用潜力.

关键词:

银纳米颗粒银纳米粒子它是一种抗菌药物,具有抗菌作用.这是一种抗癌药物.生物相容性生物相容性双二是什么意思双二是什么意思

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