活性介质素-18的动脉静脉梯度与腹功能障碍有关:一个横截面研究
Hirofumi Makino1, Yu Yasuda2, Yusuke Morita2
1Internal Medicine 1, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.
ESC heart failure
|February 19, 2026
概括
局部互白素-18 (IL-18) 梯度与心力衰竭患者的透缩功能障碍有关. 较高的活性IL-18的动脉静脉比率与心肌放松受损相关,特别是在那些充满压力较高的人群中.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 扩张性功能障碍是心力衰竭 (HF) 症状和预后的一个主要因素.
- 介素-18 (IL-18) 和IL-6是高血压中关键的炎症性细胞因子,但它们的局部作用尚不清楚.
- 这项研究探讨了动脉静脉 (A / V) 细胞因子梯度和腹功能障碍之间的联系.
研究的目的:
- 调查活跃IL-18 (aIL-18) 和活跃IL-6 (aIL-6) 的A/V梯度与腹功能障碍之间的关联.
- 评估这些细胞因子梯度与心声学和临床参数的扩张功能障碍之间的关系.
- 评估aIL-18对心脏纤维细胞的体外影响.
主要方法:
- 87名接受心脏导管治疗的心力衰竭患者被纳入研究.
- 对结合的动脉和静脉血液样本进行了aIL-18和aIL-6度分析.
- 评估了与心声回声测量 (例如,E/e'),临床分数 (HFA-PEFF) 和体外纤维细胞反应的关联.
主要成果:
- 队列中心肌放松受损,喷射分数保留.
- aIL-18 A/V比率与腹功能障碍的标志物相关联,包括平均E/e,三腹吐压力梯度和HFA-PEFF得分.
- 这些相关性在非糖尿病患者和LV填充压力升高的患者中更强;aIL-18在体外刺激纤维细胞增殖和原蛋白合成.
结论:
- 局部IL-18梯度,以aIL-18 A/V比率表示,与心力衰竭中的透缩功能障碍有关.
- 这些发现表明局部IL-18在透缩功能障碍中的作用,特别是在增加填充压力的患者中.
- 需要进一步的研究来证实这些探索性发现,并阐明涉及的机制.
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