心脏代谢指数的累积暴露与心力衰竭风险之间的关联:一项前性队列研究
Peng Fu1,2, Huancong Zheng3, Weiqiang Wu1
1Department of Cardiology, Second Affiliated Hospital of Shantou University Medical College, No. 69, Dongxia North Road, Jinping District, Shantou, Guangdong Province 515000, China.
ESC heart failure
|February 19, 2026
概括
高累积心脏代谢指数 (CMI) 随着时间的推移显著增加心力衰竭 (HF) 风险. 保持最佳CMI水平对于预防一般人群中HF至关重要.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 流行病学 流行病学
背景情况:
- 高心脏代谢指数 (CMI) 是心力衰竭 (HF) 的已知危险因素.
- 累计CMI暴露对事件HF的长期影响需要进一步调查.
研究的目的:
- 检查CMI累积暴露与发生HF事件的风险之间的关联.
- 为了评估累积CMI对心力衰竭发病率的长期影响,在一个大型前性队列中.
主要方法:
- 利用了Kailuan研究中的44773名参与者的数据,以及2006年,2008年和2010年的基线健康检查.
- 计算累积CMI并将其分类为四分位数;通过医疗记录和死亡登记册识别的事件HF直到2022年12月.
- 采用Cox比例危险模型来估计HF风险的危险比率和95%置信区间.
主要成果:
- 在平均12.0年的随访期间,发生了1018个高频事件.
- 与最低四分位数相比,最高四分位数 (Q2-Q4) 的累积CMI显示HF调整后危险比率显著增加 (趋势P<0.001).
- 在累积CMI和糖尿病之间发现了显著的相互作用 (P = 0.043),但与年龄,性别或高血压没有显著的相互作用.
结论:
- 高累积心脏代谢指数独立地与心力衰竭风险增加有关.
- 长期监测和保持最佳CMI水平可能是早期HF识别和预防的关键策略.
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