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强化母乳使用的围产和实验室决定因素:一个病例控制研究

C B G Tavares¹, J M V Zacarias^1,2, V H Souza³

¹Programa de Pós-Graduação em Biociências e Fisiopatologia, Universidade Estadual de Maringá, Maringá, PR, Brasil.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

|February 19, 2026

概括

用FM85®强化母乳在出生时体重低,头周长改变或剖腹产的非常早产婴儿中更为常见. 强化并没有显著改变大多数实验室值,但可能提供一种生理替代方案.

科学领域:

新生儿科学新生儿科学
儿童营养学儿童营养学
婴儿免疫学婴儿免疫学

背景情况:

过早出生的婴儿,特别是低出生体重 (LBW) 的婴儿,需要专门的营养支持.
人母乳 (HM) 强化在新生儿重症监护室 (NICU) 常见,以满足早产婴儿的高营养需求.
特定强化剂,如FM85®,对LBW早产婴儿的实验室参数和围产因素的影响需要进行调查.

研究的目的:

为了比较早产婴儿接受非强化HM和接受FM85®强化HM的婴儿之间的围产和实验室因素.
为了确定与使用HM强化在LBW早产婴儿中相关的围产特征.
评估HM强化对LBW早产婴儿实验室值的影响.

主要方法:

一项涉及38名LBW早产婴儿在NICU的病例控制研究.
围产期变量 (妊娠年龄,出生体重,头周长,分娩方式) 和实验室值的分析.
统计分析包括千平方测试,学生的t测试,克鲁斯卡尔-瓦利斯测试和曼-惠特尼测试.

主要成果:

非常早产的婴儿,那些患有LBW,体重进展不佳,头周长变化和剖腹产的婴儿更有可能接受FM85®强化.
中性粒细胞数量下降,而淋巴细胞数量在两组中都增加.
红细胞和血红蛋白水平恶化;在两组中,和水平显著增加.
用FM85®强化HM并没有显著改变大多数实验室值,除了红细胞计数.

结论:

低腰,头周长变化和剖腹产与使用HM强化剂的可能性增加有关.
在早产婴儿中观察到免疫学变化,不论强化.
像FM85®这样的同类强化剂可能代表LBW早产婴儿的更生理的营养方法.

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