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Updated: May 7, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
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环金属复合物作为有前途的抗菌药物

Innokentii E Vishnyakov1, Anton Y Plekhanov2, Andrew V Goodkov3

  • 1Institute of Cytology, Russian Academy of Sciences, 194064, St. Petersburg, Russia. innvish@incras.ru.

Naunyn-Schmiedeberg's archives of pharmacology
|February 19, 2026
PubMed
概括

帕拉复合物显示出有限的抗癌活性,但显示出对菌体病原体的潜在作用. PdEnC6和PdEnBhq表现出与商业药物相当的抗菌特性,这表明它们用于治疗感染.

关键词:
抗微生物活性 抗微生物活性癌细胞 癌细胞 癌细胞细胞毒性 细胞毒性菌质体是什么 菌质体其他非癌细胞.帕拉 (II) 循环金属复合物的复合物

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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