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解读肝肌沟通在健康和疾病中的机制基础

Noha M Gamil¹, Habiba A Elsayed², Esraa T Salah²

¹Department of Pharmacology and Toxicology, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology (MUST), P.O. Box 77, Giza, Egypt. noha.mohsen@must.edu.eg.

Naunyn-Schmiedeberg's archives of pharmacology

|February 19, 2026

概括

肝脏和骨肌肉双向通信,影响整体健康. 了解这种肝肌交互是开发针对影响两器官的代谢疾病的新疗法的关键.

科学领域:

生理学生理学生理学
代谢疾病代谢疾病
分子生物学分子生物学

背景情况:

肝脏和骨肌肉有一个关键的,但尚未探索的,双向通信轴.
一个器官的功能障碍可以加速另一种器官的病理,放大疾病的进展.
了解这种相互连接的系统对于有针对性的治疗策略至关重要.

研究的目的:

阐明肝肌交叉通话的复杂病理生理机制.
为了确定在两个器官同时干预的新型治疗点.
对肝肌轴的分子途径,生物标志物和治疗干预措施进行审查.

主要方法:

对同行评审研究的综合文献综述.
分子通路的分析,包括炎症调解剂 (TNF-α,IL-6) 和代谢调节剂 (mTOR,AMPK).
检查肝激素,肌激素,心激素和生物标志物,如 zonulin.

主要成果:

肝肌交叉涉及炎症级联,代谢干扰 (胰岛素抵抗,AMPK功能障碍) 和肠-肝-肌肉相互作用.
肝激素-肌激素信号网络协调新陈代谢平衡.
肝心交叉反应与骨肌肉反应不同,涉及特定的途径,如FGF21和IL-6/STAT3.

结论:

研究肝肌轴改变了对代谢疾病的理解,从孤立的病理学到全身性疾病.
这一框架为精准医学,生物标志物开发和治疗提供了新的途径.
通过有针对性的干预措施,可以同时优化肝脏,骨肌肉和心脏健康.

关键词:

肝激素 (hepatokines) 是一种肝激素.肝脏纤维化肝脏纤维化肝肌肉轴肝肌肉轴马斯尔德马斯尔德是什么意思咪奥金斯 (Myokines) 是一种神经元.萨尔科佩尼亚是什么意思萨尔科佩尼亚

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