静脉动脉冲动脉退出部位位于心肌再生内核区内,预测缺血性心肌病的血液动力稳定性
Jorge L Reyes1,2, Darshan Krishnappa1, Lucy Q Lin3
1Advanced Interventional Cardiac Electrophysiology, LAA Closure Program, Cardiovascular Division, Minneapolis VA Health Care System, University of Minnesota, Minneapolis, MN, 55417, USA.
概括
腹腔动脉冲动 (VT) 出口地点位于中央痕区域附近,预测血液动力学不稳定. 围心梗塞边界区域的出口与稳定的VT相关,有助于风险分层和废除策略.
科学领域:
- 心脏病学 心脏病学
- 电子生理学 电子生理学
- 心脏外科手术 心脏外科手术
背景情况:
- 在心室低心率 (VT) 期间的血液动力学稳定性对于成功的映射和切除至关重要.
- 缺血性痕介导的静脉瘤由于潜在的血液动力学损害而带来了重大挑战.
研究的目的:
- 为了研究静脉瘤退出部位位于不同心肌痕区内的位置对血液动力学稳定性的影响.
- 为了确定痕区域的特征是否影响缺血性静脉瘤的血液动力学稳定性.
主要方法:
- 在27名患有缺血性痕介导性静脉瘤的患者中分析了51例静脉瘤,使用了电解剖绘图和导管切除.
- 在双极电压的基础上,将VT退出点分为中央痕区 (CSZ) 或围心梗塞边界区 (PIBZ) 的分类.
- 血液动力学稳定性的定义和使用多变量逻辑回归的预测因素的识别.
主要成果:
- 58.8%的VTs在血液动力学上不稳定.
- 稳定的VTs主要来自PIBZ (81%),而不稳定的VTs通常来自CSZ (19%).
- 独立预测的血液动力学不稳定性 (OR 6.8,P = 0.02),不稳定的VTs显示较低的射出分数和较短的周期长度.
结论:
- 相对于心肌痕区域,静脉瘤退出部位的位置是血液动力学稳定的独立预测指标.
- 中央痕区域的出口与血液动力学不稳定性有关,而围心脏病发作边界区域的出口与稳定性相关.
- 研究结果表明,在缺血性静脉瘤中,差异性再生内核和机械力量影响了风险分层和废弃策略.
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