免疫疗法处方模式和与头癌患者的免疫相关不良事件
Andrew M Peterson1,2, Dustin Stwalley3, Dorina Kallogjeri2,4
1Robert Ebert and Greg Stubblefield Head and Neck Tumor Center at Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri.
JAMA otolaryngology-- head & neck surgery
|February 19, 2026
概括
自批准以来,65岁以下的头癌 (HNC) 患者的免疫疗法使用量略有增加,布罗利祖马布占据市场主导地位. 与免疫相关的不良事件 (irAEs) 是常见的,与并发症相关,而严重的irAEs是罕见的.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床研究 临床研究
背景情况:
- 免疫疗法是针对复发性/转移性头癌 (HNC) 的批准的一线治疗方法.
- 在HNC患者中,处方模式和与免疫相关的不良事件 (irAEs) 仍未得到报告.
- 在接受免疫治疗的HNC患者中评估irAEs对于临床管理至关重要.
研究的目的:
- 评估HNC患者免疫疗法处方趋势.
- 确定与该群体中irrEs相关的发病率和风险因素.
- 分析不同免疫治疗剂的市场份额.
主要方法:
- 使用MarketScan商业和医疗补助数据库 (2016-2022) 的回顾性队列研究.
- 包括患有HNC的患者 (ICD-10-CM代码),不包括65岁及以上的患者.
- 分析免疫疗法处方率,irAE发生率和irAE的风险因素.
主要成果:
- 在47365名HNC患者中,4.8%接受了免疫治疗;处方率略有增加,从2.3% (2017) 增加到2.8% (2022).
- 布罗利祖马布主导市场,到2022年占据87%的市场份额.
- 90天的整体IRAE率为41.2%,严重的IRAE率为2.7%. 甲状腺功能低下和肝脏疾病与irAEs有关.
结论:
- 布罗利祖马布是HNC的领先免疫疗法,但整体免疫疗法在65岁以下的患者中增长很小.
- 在HNC患者中,irrAEs很常见,具有特殊的并发症,如甲状腺功能低下症和肝病,增加了风险.
- 严重的IREs很少发生,并且与整体并发症负担有关.
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