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Updated: Feb 21, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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Published on: July 25, 2020

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在晚期乳腺癌中使用一线与二线CDK4/6抑制剂的整体生存率:一项随机临床试验

Noor Wortelboer1, Annemiek van Ommen-Nijhof2, Inge R Konings3

  • 1Department of Medical Oncology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.

JAMA oncology
|February 19, 2026
PubMed
概括

与二线使用相比,第一线循环素依赖性激酶4和6抑制剂 (CDK4/6i) 并没有改善晚期乳腺癌的整体存活率. 然而,一线CDK4/6i在绝经前患者中显示出生存益处,并增加了毒性作用.

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