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酶修饰的含有DOPA的丝纤维蛋白生物粘合剂具有动态交叉连接特性

Yurong Tan^1,2, Haopeng Li¹, Xiao Han³

¹Mechano-X Institute, Applied Mechanics Laboratory, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China.

ACS applied materials & interfaces

|February 19, 2026

概括

研究人员使用酶交叉连接策略开发了一种新的基于丝的水凝. 这种生物粘合剂为先进的生物电子应用提供快速凝,强粘合和自我愈合.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
生物电子学生物电子学

背景情况:

丝纤维素 (SF) 水凝与同时快速凝,机械强度,自我愈合和对表皮生物电子的粘合力作斗争.
目前的局限性来自于低效的交叉连接和缺乏活跃的粘合成分.

研究的目的:

开发高性能,全丝生物粘合剂,使用酶动态交叉链接策略.
克服传统的SF水凝的局限性,用于先进的生物电子接口.

主要方法:

为了在SF中改进DOPA转化,进行了工程类氨酶 (TYR) 选择.
利用pH触发的Fe3+协调来实现动态交叉链接.
为机械性能,粘附性和自我愈合而制造和特征化丝基水凝.

主要成果:

与商业酶相比,鉴定了一种具有6.8倍高的DOPA转化产率 (2.7mol%) 的细菌氨酶.
形成的水凝具有可调节的机械性能 (3-13 kPa模量,>250%应变) 和高粘附性 (18-40 kPa).
证明了出色的自我愈合能力,生物相容性,并成功地集成到可穿戴的汗液传感器中.

结论:

建立了一个可通用的酶策略,用于创建基于纯蛋白质的动态水凝.
开发的生物粘合剂适用于先进的生物接口,包括表皮生物电子和可穿戴传感器.
这种方法可以设计具有定制性质的高性能丝生物材料.

关键词:

动态交叉连接动态交叉连接人机界面的人机界面皮肤间歇液体皮肤间歇液体再组合型铁酶的使用.丝纤维蛋白生物粘合剂

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