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Updated: May 5, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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AgOTf - 催化 1,4-添加本佐福衍生阿扎迪因 (BDAs) 与亚纳米德

Hui-Hong Tian1,2, Xiao-Lin Liu2, Ai-Mei Yang1

  • 1School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, China.

The Journal of organic chemistry
|February 19, 2026
PubMed
概括

研究人员开发了一种新的AgOTf催化反应,用于合成使用酸衍生阿扎迪烯 (BDA) 和酸的替代3-酸-2-) 胺基. 在这种高效的转型中,水起着至关重要的作用,可以获得中等到良好的产量.

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Simple aryl halides do not react with nucleophiles. However, nucleophilic aromatic substitutions can be forced under certain conditions, such as high temperatures or strong bases. The mechanism of substitution under such conditions involves the highly unstable and reactive benzyne intermediate. Benzyne contains equivalent carbon centers at both ends of the triple bond, each of which is equally susceptible to nucleophilic attack. This 50–50 distribution of products is...
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Arenediazonium substitution reactions occur when the diazonium group is substituted by various functional groups such as halides, hydroxyl, nitrile, etc. For instance, arenediazonium salts react with copper(I) salts of chloride, bromide, or cyanide to form corresponding aryl chlorides, bromides, and nitriles. These reactions are named Sandmeyer reactions. Although the mechanism of this reaction is complicated, as illustrated in Figure 1, they are believed to progress via an aryl copper...
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