超过3000个表型的安全组和专业面板:使用人类遗传学和药理学的系统和翻译方法
Xin Liu1, Yen-Wei Chen1, Xiao Xu2
1Preclinical Sciences & Translational Safety, Johnson & Johnson.
概括
药物开发人员现在可以使用11000多种蛋白质的扩展安全组来选潜在的安全危险. 这种全面的资源,包括专门的小组,有助于药物安全性评估和问题解决.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 计算生物学 计算生物学
- 遗传学 遗传学 是一个
背景情况:
- 药物候选药物评估需要评估目标之外的活动,以预测安全风险并了解机制.
- 将体外发现转化为体外结果对于选择相关的目标外结果至关重要.
- 人类遗传学和药理学数据库为识别潜在的安全问题提供了宝贵的见解.
研究的目的:
- 通过策划和优先考虑非目标目标来开发一个全面的药物安全性评估资源.
- 扩大安全查的范围,包括更广泛的器官系统和表型.
- 创建一个用户友好的平台,用于有效的安全评估和药物开发中的问题解决.
主要方法:
- 利用增强的自然语言处理工具来分析来自7个遗传学和2个药理学数据库的数据.
- 将生物角色映射到22个器官系统中,以创建一个由11000多种蛋白质组成的扩展安全组.
- 使用表达模式和基因保护来优先确定目标,生成一个由500个目标组成的核心面板和3000多个专业面板.
主要成果:
- 一个由超过11000个涉及22个器官系统的蛋白质组成的扩大安全组被策划.
- 由500个目标组成的优先级核心面板和3000多个基于表型的专业面板被生成.
- 所有成分都使用来自比较毒基因组学数据库的独立基因表达数据进行了验证.
结论:
- 开发的安全组,核心小组和专业小组为药物安全性评估提供了强大的资源.
- 这款用户友好的应用程序有助于有效的安全评估和解决问题,并以翻译为重点.
- 这种全面的方法显著提高了识别和解决潜在药物相关安全问题的能力.
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